CERODROL
- For Intravenous use 1gm
- Penicillinase-resistant penicillins (flucloxacillin) remain the antibiotics of choice for the
- Management of serious methicillin-susceptible S. aureus (MSSA) infections
- In Catheter-related MSSA bacteremia Initial IV regimen is flucloxacillin 25mg/kg up to 1g q6h
- In CABG or other non-prosthetic procedure Flucloxacillin isthe recommended prophylactic antibiotic
- In CoNS the first line empiric treatment for late onset sepsis (>48 h) is flucloxacillin
Antibiotic prophylaxis in surgery (ADULTS)
Pharmacokinetic data
Antibiotic prophylaxis in surgery (ADULTS)
| CABG or other non-prosthetic procedure | IV Flucloxacillin 1g at induction (plus further 1g intraoperatively if operation lasts > 3hours) then a further 3 doses of 1g at 6 hourly intervals on CICU. PLUS IV Gentamicin160mg at induction (all patients). |
| Flucloxacillin 2g i.v. stat at induction +/- Metronidazole 500mg i.v. stat at induction (at surgeon’s discretion) |
| Flucloxacillin 2g i.v. stat at induction +/- Metronidazole 500mg i.v. stat at induction followed by: Flucloxacillin 1g i.v. 6hourly + Metronidazole 500mg i.v. 8hourly Until drains are removed Switch to oral antibiotics can be considered at 48 hours. |
| Flucloxacillin 1g i.v. stat at induction + Gentamicin 240mg*§ i.v. stat at induction + Metronidazole 500mg i.v. stat at induction Gentamicin level not required at surgeon’s discretion may give up to 2 further doses of Flucloxacillin 500mg i.v. 6hourly + Metronidazole 500mg i.v. 8hourly (No further gentamicin) |
| Flucloxacillin 1g i.v. stat at induction |
| Flucloxacillin 1g i.v. stat at induction + Metronidazole 500mg i.v. stat at induction followed by: Flucl oxacillin 1g iv 6hourly (3 doses) + Metronidazole 500mg i.v. 8hourly (2 doses) |
| Flucloxacillin 1g i.v. stat at induction + Metronidazole 500mg i.v. stat at induction followed by: Flucloxacillin 1g iv 6hourly (3 doses) + Metronidazole 500mg i.v. 8hourly (2 doses) If implant followed by: Flucloxacillin 500 mg p.o. 6hourly for 5 days |
Pharmacokinetic data
| Bioavailability | 50–70% |
|---|---|
| Metabolism | Hepatic |
| Biological half-life | 0.75–1 hour |
| Excretion | Renal |